Regeneron Says Its Covid-19 Outpatient Therapy Could Reduce Virus Levels

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Regeneron Says Its Covid-19 Outpatient Therapy Could Reduce Virus Levels

By RTTNews Staff Writer | Published: 10/29/2020 6:42 AM ET

Regeneron announced positive results from its late stage COVID-19 outpatient trial, indicating that its antibody cocktail therapy significantly reduced virus levels and need for further medical attention. The trial results showed that investigational antibody cocktail, REGN-COV2, met the primary and key secondary endpoints.

The biotechnology company has shared these results with the U.S. FDA, which is reviewing an Emergency Use Authorization submission for the REGN-COV2.

Following the news, Regeneron shares were gaining around 2.3 percent in pre-market activity on Nasdaq, and were gaining 4 percent in France.

REGN-COV2 is a combination of two monoclonal antibodies, such as REGN10933 and REGN10987, and was designed specifically to block infectivity of SARS-CoV-2, the virus that causes COVID-19.

The ongoing Phase 2/3 seamless trial in the COVID-19 outpatient setting is measuring the effect of adding REGN-COV2 to usual standard-of-care, compared to adding placebo to standard-of-care.

In the trial, REGN-COV2 significantly reduced viral load and patient medical visits, including hospitalizations, emergency room, urgent care visits and/or physician office/telemedicine visits.

The initial data in 275 patients strongly suggested that the REGN-COV2 antibody cocktail could lower viral load and thereby potentially improve clinical outcomes.

The latest trial data, involving an additional 524 patients from the ongoing Phase 2/3 trial, provides definitive final virology results and meets the clinical endpoint of reducing medical visits.

On the key clinical endpoint, treatment with REGN-COV2 reduced COVID-19 related medical visits by 57 percent through day 29, and by 72 percent in patients with one or more risk factor.

Regeneron said the Phase 3 portion of this trial continues in non-hospitalized patients.

REGN-COV2 is also being studied in a Phase 2/3 clinical trial for the treatment of COVID-19 in hospitalized patients, the Phase 3 open-label RECOVERY trial of hospitalized patients in the UK and a Phase 3 trial for the prevention of COVID-19 in household contacts of infected individuals.

For comments and feedback contact: editorial@rttnews.com

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Article written by an RTT News Staff Writer, and posted on the RTT News.com website.

Article reposted on Markethive by Jeffrey Sloe

Ethereum Held on Exchanges Hits 268M ETH 237 of Circulating Supply

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Ethereum Held on Exchanges Hits 26.8M ETH, 23.7% of Circulating Supply

John P. Njui   •   ETHEREUM (ETH) NEWS   •   OCTOBER 29, 2020

Summary:

  • 26.81 million Ethereum is held on centralized exchanges
  • This is 23.7% of Ethereum’s circulating supply
  • Majority of the ETH is held at Coinbase, Bitfinex and Huobi
  • Ethereum is once again above $390 and looking ready to attempt $400 once again

The amount of Ethereum held on centralized exchanges currently stands at 26.81 million ETH. This is according to data from CryptoRank Platform. This amount is also 23.7% of Ethereum’s circulating supply. Of this amount, the majority of the Ethereum is held on Coinbase (8.52 million ETH), Bitfinex (5.27 million ETH) and Huobi (3.26 million ETH). Binance and Kraken wallets currently hold 2.95 million ETH and 2.43 million ETH respectively.

Ethereum is Once Again Trading Above $390 and Could Retest $400

In terms of the current value of Ethereum, ETH is once again attempting to claim the $390 resistance area as support. At the time of writing, Ethereum is trading exactly at $390 amidst the Bitcoin revival that has seen the King of Crypto bounce back from $12,900 levels to $13,487.

The bullishness of Bitcoin is one reason Ethereum could just turn the $390 price area into support and possibly attempt $400 in the days ahead. This is despite the fact that the daily ETH/USDT chart clearly hints of a correction for Ethereum. If Bitcoin can retest its recent high of $13,869, Ethereum might once again trade above $400.


(Click image for larger view)

Taking a closer look at the daily ETH/USDT chart above, the following can be observed.

  • Trade volume is in the red but hinting at a reduction in selling
  • The daily MACD is about to cross in a bearish manner above the baseline
  • The daily MFI and RSI point towards a correction for Ethereum at a value of 60 and 54 respectively
  • However, Ethereum’s price is above the 50, 100 and 200-day moving averages further foreshadowing a push up for Ethereum based on Bitcoin’s market momentum
  • The 50-day and 100-day MAs provide considerable support at the $380 price area

As with all analyses of Ethereum, traders and investors are advised to have an eye out for any Bitcoin moves that might ruin the party. Additionally, stop losses are advised given the fact that Bitcoin tends to ‘suck the capital’ from Ethereum and alts whenever it pumps hard.

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Original article posted on the EthereumWorldNews.com site, by John P. Njui.

Article re-posted on Markethive by Jeffrey Sloe

Loan refinancer and BitLicensee SoFi is clear to launch a national bank in the US

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Loan refinancer and BitLicensee SoFi is clear to launch a national bank in the US

The new bank will be subject to heightened scrutiny from the OCC for at least three years.


Image courtesy of CoinTelegraph

            OCT 28, 2020

In an announcement on Wednesday, the Office of the Comptroller of the Currency (OCC) granted SoFi a conditional license to operate as a national bank in the United States.

The OCC is the office of the U.S. Treasury that regulates federal banks throughout the country. SoFi, which stands for Social Finance, is a fintech startup that has historically provided loans and refinancing services. In 2019, the firm launched crypto trading, and last December, the New York Department of Financial Services granted SoFi a coveted BitLicense.

This new license will enable the firm to offer a wider range of services. Just today, the firm announced that it was also releasing a credit card with cashbash rewards that paid down personal and student debt

For its part, the OCC makes clear that SoFi Bank must clear certain hurdles for its charter to leave conditional status. Initial capital will be $550 million, of which the OCC requires 30% to be in cash.

The OCC could not be reached for comment as of publication time.

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Original article posted on the CoinTelegraph.com site, by Kollen Post.

Article re-posted on Markethive by Jeffrey Sloe

Is the US Presidential Election Bitcoin’s Next Big Catalyst?

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Is the U.S. Presidential Election Bitcoin’s Next Big Catalyst?

By Mr Oak – October 28, 2020

As the US presidential election looms, the crypto market, in general, is wide awake and alert as to what lies ahead afterward. There is a cloud of uncertainty hovering above investors as many have already begun switching to assets such as Gold, silver, and Bitcoin as they are seen as a safe-haven as compared to other digital and traditional assets.

It is no secret that this upcoming US presidential election would be one of the fiercest competitions in the history of politics. The US economy has been battered for months now due to the COVID pandemic and as such has led to the collapse of the dollar index. In this same period, Bitcoin was expected to rise unprecedentedly, post its halving event coupled with the uncertainty of the traditional financial market but that hasn’t been the case so far. The mainstream and crypto market needs money coming in to flourish and that also doesn’t seem to be happening as the working class is holding their capital until the aftermath of the elections.

There is no easy likely outcome of the election as both parties are poised to win. The question however is, what the outcome holds in store, especially for the Bitcoin community. Both Presidential candidates haven’t voiced out much of an opinion on the topic of cryptocurrencies. However, their Fairly diplomatic and impartial stand of cryptocurrencies will inevitably change as institutional inflow, traditional financial corporations’ migration into cryptocurrency as well as the increased scrutiny surrounding global central bank digital currencies are all factors that will demand acknowledgment and a strategic approach.

As the potential of the outcome remains open, safe-haven demand will continue to rise. Market swings, tax policies as well as regulatory uncertainties could lead to a negative reaction from the traditional financial market which will increase the number of investors seeking to hold their capital in assets deemed safe. In other words, Bitcoin will likely benefit from a negative reaction to the outcome of the election. As Gold and Silver remain the preferred choice for traditional investments, Bitcoin is undoubtedly the safe option to go for amongst cryptocurrency investors.

Using the general election as a determined catalyst to influence investment decisions without the benefit of hindsight could be tricky. However, Bitcoin has been one of the best-performing assets this year, with more than a gain of 70%.

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According to experts, the weakness of the U.S dollar will further fuel the growth of the digital currency for the rest of the year and this will still be as a result of political uncertainty after the elections where investors will be compelled to observe the economy and market as to how it will perform whilst still having their capital piled up in safe-haven assets. In a situation where the financial scene remains calm after the elections, a rise in the stock market could also be a win for Bitcoin as the digital coin has shown signs or correlation with the stock market this year.

Bitcoin was trading 195% higher than its yearly low ($13,264) at the time of this piece, still rising after breaking above the $13k mark which became somewhat of a psychological barrier for weeks.

DISCLAIMER

The views expressed in the article are wholly those of the author and do not represent those of, nor should they be attributed to, ZyCrypto. This article is not meant to give financial advice. Please carry out your own research before investing in any of the various cryptocurrencies available.

The original article written by Mr Oak and posted on ZyCrypto.com.

Article reposted on Markethive by Jeffrey Sloe

JPMorgan Coin Is Now Live And In Use By A Large Technology Client For Global Payments

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JPMorgan Coin Is Now Live And In Use By A “Large Technology Client” For Global Payments

By Brenda Ngari – October 28, 2020

The largest US bank with around $2.7 trillion assets under management, JPMorgan & Chase, has launched its own stablecoin, the JPM Coin. The newly-released JPM Coin is reportedly being used commercially by a large tech client for the very first time this week.

JPMorgan is also exploring the creation of new separate payment rails for central banks around the world that have shown interest in developing their own digital currencies. Citing China and Singapore, Takis Georgakopoulos, JPMorgan’s global head of wholesale payments is certain the probability of adoption of such a model is “very high”. This is according to a report by CNBC on October 27.

After A Long Wait, JPM Coin Is Finally Here

While the transnational tech firm leveraging JPM Coin has not been named, Georgakopoulos revealed that this firm will be using the stablecoin to settle global payments in real-time.

This unmistakable proof that blockchain technology is slashing costs and increasing overall efficiency has given the multinational banking giant confidence that the technology is profitable and promising.

Along these lines, JPMorgan has launched a new business unit called “Onyx” that will house the firm’s blockchain and digital currency initiatives. This business unit comes in handy as JPMorgan expects more commercial clients to get onboard. Onyx will have over 100 staffers, with Umar Farooq as the newly appointed CEO.

Speaking about the unit, Georgakopoulos stated:

“We are launching Onyx because we believe we are shifting to a period of commercialization of those technologies, moving from research and development to something that can become a real business.”

Using Blockchain’s Usefulness To Revolutionize The Existing Outdated Banking System

According to the report, JPMorgan recognizes blockchain technology’s usefulness in providing a solution for the exorbitant costs incurred in processing checks as well as reducing the time spent before payment clears.

Per Georgakopoulos, “Using a version of blockchain with the participants being the main issuers of checks and the main operators of lockboxes, it’s possible we can save 75% of the total cost for the industry today, and make checks available in a matter of minutes as opposed to days.”

One might ask why JPMorgan has taken too long to embrace blockchain if it has so much faith in the technology’s usefulness. Well, Onyx CEO Farooq explained:

“If you think about blockchain, we are either somewhere in the trough of disillusionment or just beyond that on the hype curve. That’s why at JPMorgan we’ve been relatively quiet about it until we were ready to scale it and commercialize it.”

Farooq, however, noted that this project is months away from its commercial launch.

Quick Facts About JPM Coin

JPMorgan first announced its JPM Coin back in February 2019. The token bears some similarities to a stablecoin as it is pegged 1:1 to the United States dollar. More interestingly, JPM Coin was built on top of Quorum, a permissioned ethereum fork developed in-house by the bank. In August, however, JPMorgan invested in ethereum venture studio ConsenSys, and the blockchain company would acquire and manage Quorum on behalf of JPMorgan as part of the strategic deal. 

JPM Coin was designed with the main focus of accelerating transactions such as inter-firm payments and bond transactions. The bank started conducting trials of the token early last year.

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DISCLAIMER

The views expressed in the article are wholly those of the author and do not represent those of, nor should they be attributed to, ZyCrypto. This article is not meant to give financial advice. Please carry out your own research before investing in any of the various cryptocurrencies available.

The original article written by Brenda Ngari and posted on ZyCrypto.com.

Article reposted on Markethive by Jeffrey Sloe

Lilly In Deal To Supply 300000 Vials Of COVID-19 Drug Bamlanivimab To US Govt For 375 Mln

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Lilly In Deal To Supply 300,000 Vials Of COVID-19 Drug Bamlanivimab To U.S. Govt For $375 Mln

By RTTNews Staff Writer | Published: Published: 10/28/2020 7:14 AM ET

Eli Lilly and Co. (LLY) announced Wednesday an initial agreement with the U.S. government to supply 300,000 vials of bamlanivimab (LY-CoV555) 700 mg for $375 million in an effort to fight COVID-19.

Bamlanivimab is a potent, neutralizing IgG1 monoclonal antibody or mAb directed against the spike protein of SARS-CoV-2. Lilly in early October submitted a request for an Emergency Use Authorization or EUA for bamlanivimab to the FDA for the treatment of mild to moderate COVID-19 in high-risk patients.

If FDA grants an EUA, the U.S. government will accept the vials of bamlanivimab, which will be delivered over the two months following an EUA. The agreement also provides the option for the U.S. government to purchase up to an additional 650,000 vials through June 30, 2021, under the same terms.

Lilly has successfully completed a Phase 1 study of bamlanivimab in hospitalized patients with COVID-19 (NCT04411628). A Phase 2 study in people recently diagnosed with COVID-19 in the ambulatory setting (BLAZE-1, NCT04427501) is ongoing.

Further, a Phase 3 study of bamlanivimab for the prevention of COVID-19 in residents and staff at long-term care facilities (BLAZE-2, NCT04497987) is also ongoing. Bamlanivimab is also is being tested in the National Institutes of Health-led ACTIV-2 study of ambulatory COVID-19 patients.

The company's discussions with global regulators are ongoing.

The U.S. government has further committed that patients will have no out-of-pocket costs for the medicine, if granted EUA, although healthcare facilities may charge a fee for the product's administration.

The company noted that the federal government, in partnership with state health departments, is developing a government allocation program for bamlanivimab. As part of this government program, Lilly is partnering with Operation Warp Speed and a national distributor to finalize distribution plans and shipping preparations, should an EUA be granted.

Lilly anticipates manufacturing up to one million doses of bamlanivimab 700 mg by the end of 2020, with 100,000 doses ready to ship within days of authorization.

For comments and feedback contact: editorial@rttnews.com

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Article written by an RTT News Staff Writer, and posted on the RTT News.com website.

Article reposted on Markethive by Jeffrey Sloe

Southeast Asia’s Largest Bank Is Launching Crypto Trading And Custody For Bitcoin Ethereum And XRP

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Southeast Asia’s Largest Bank Is Launching Crypto Trading And Custody For Bitcoin, Ethereum, And XRP

By Brenda Ngari – October 27, 2020

The largest retail and commercial bank in Southeast Asia by assets, DBS, is seemingly planning to launch a digital assets platform for the trading and custody of major cryptocurrencies. According to an announcement that was posted accidentally and deleted, the forthcoming crypto offering — the DBS Digital Exchange — is backed by the Singapore-headquartered bank and regulated by the Monetary Authority of Singapore (the country’s central bank).

The fiat-to-crypto exchange will “leverage an integrated ecosystem of solutions to tap the vast potential of private markets and digital currencies”. In particular, it will support five top cryptos including bitcoin (BTC), Ethereum (ETH), XRP, Bitcoin Cash (BCH), and Ethereum Classic (ETC). Users will be able to trade these cryptocurrencies against the United States Dollar (USD), the Singapore dollar (SGD), the Japanese Yen (JPY), and the Hong Kong dollar (HKD).

What’s unique about this digital assets exchange is that it will not be holding any assets itself. Instead, “all digital assets are kept at DBS Bank, which is globally recognized for its custodial services”. The now-deleted announcement highlights that DBS has set up an “institutional-grade” custody solution called DBS Digital Custody.

Additionally, DBS Digital Exchange will also allow SMEs and large corporations alike to issue security tokens in the foreseeable future.

Before the announcement was taken down, industry leaders touted the move as another huge milestone for the cryptocurrency space. Binance CEO Changpeng Zhao, for instance, tweeted:

Ryan Sean Adams, crypto investor and founder of Mythos Capital, postulated:

“The largest bank in Singapore just launched a crypto exchange. All banks are sidechains of Ethereum and Bitcoin. They just don’t know it yet.”

The year 2020 has seen a flurry of good news for the nascent asset class. The uncertainty caused by the COVID-19 pandemic and the forthcoming US elections has certainly strengthened the investment case for crypto. 

DBS’s announcement comes after US payments behemoth PayPal embraced cryptocurrency last week. Business intelligence firm MicroStrategy, Jack Dorsey’s Square, and $10 billion asset manager Stone Ridge revealed substantial investments in the bellwether cryptocurrency.

With all these developments (and more on the way), bitcoin’s likelihood of surging higher in the coming weeks and months has increased significantly. Bitcoin is currently trading at $13,631.25, up 1.72% so far today.

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DISCLAIMER

The views expressed in the article are wholly those of the author and do not represent those of, nor should they be attributed to, ZyCrypto. This article is not meant to give financial advice. Please carry out your own research before investing in any of the various cryptocurrencies available.

The original article written by Brenda Ngari and posted on ZyCrypto.com.

Article reposted on Markethive by Jeffrey Sloe

ChainLink LINK Retakes 12 Amidst a Bullish Bitcoin

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ChainLink (LINK) Retakes $12 Amidst a Bullish Bitcoin

John P. Njui   •   CHAINLINK (LINK) NEWS • DEFI   •   OCTOBER 27, 2020

Summary:

  • ChainLink is once again attempting to retake the $12 price area and turn it into support
  • LINK’s bullishness comes after Bitcoin retakes $13k and prints a 2020 peak at $13,498
  • Binance has added ChainLink as collateral on its Loans platform

ChainLink (LINK) is once again exhibiting bullish momentum after Bitcoin pushed hard above $13k to post a 2020 peak at $13,498 – Binance rate. ChainLink regaining its bullish momentum after Bitcoin’s pump is the result of a more than two-year relationship between LINK and BTC. This relationship has been highlighted several times by veteran crypto analyst, Timothy Peterson, of Cane Island Alternative Advisors as can be seen in his tweet below.

LINK Attempts to Turn $12 into Support

At the time of writing, LINK is trading at $12.07 after testing the lower $11 levels yesterday. The latter price level of around $11.20 was as a result of the stock markets opening in the red after news of increasing COVID19 cases in the United States and in Europe. Furthermore, traders and investors have concluded that the US House of Representatives, will not pass a second stimulus bill before the elections. This means there will be no new funds to boost the US economy until after the elections.

Shifting focus back at ChainLink its current price is only a few cents shy of the $12 resistance zone that had acted as support through this past weekend as LINK closed the week at around $12.25.

ChainLink as added as Collateral on Binance Loans

ChainLink’s attempt to hold $12 might be aided by LINK being added as a collateral option on Binance Loans. This can loosely be translated to mean that users of Binance Loans will prefer to use LINK as collateral given the possibility of the digital asset to gain value with time as predicted numerous times by crypto analysts.

The team at Binance Loans also added Tezos (XTZ) as collateral while removing Tether (USDT) as an option for the same.

Can ChainLink (LINK) Reclaim Past Glory

The big question now on the minds of LINK marines is whether ChainLink can regain the momentum seen in the month of August when it set a new all-time high at $20. This question can only be answered once ChainLink (LINK) retakes several support levels on the way to the top particularly those at $1 dollar intervals. These include the short term resistance at $12, $13, $14 and $15.

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Original article posted on the EthereumWorldNews.com site, by John P. Njui.

Article re-posted on Markethive by Jeffrey Sloe

Whale alert crypto user moves 11B in Bitcoin

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Whale alert — crypto user moves $1.1B in Bitcoin

An anonymous crypto holder just completed the largest dollar value Bitcoin transaction in history.


Image courtesy of CoinTelegraph

            OCT 03, 2020

With Bitcoin’s price continuing to hold close to $13,000, one crypto wallet has moved more than $1 billion of the digital asset.

According to on-chain data, a Bitcoin (BTC) wallet holder moved more than 88,857 BTC — worth roughly $1.15 billion — for a fee of only 0.00027847 BTC, or $3.58 at time of publication. The coins were confirmed in block 654,364 on Oct. 26.

Data from analytics platform CrystalBlockchain appears to show that the user sent the coins from an address labeled as a Xapo Bitcoin wallet. Because Coinbase Custody acquired Xapo’s institutional business in 2019, it is possible that the $1.1 billion in Bitcoin originated from the U.S.-based exchange.

This transaction is the largest movement of any cryptocurrency by fiat value, with the Bitfinex exchange setting the previous record in April. It transferred 161,500 BTC — $1.1 billion at the time — for a fee of only $0.68.

Neither of these transactions were actually the largest amount of Bitcoin to ever be moved. That honor goes to a 550,000 BTC transaction made on November 16, 2011 by the Mt. Gox exchange. Worth $1.32 million at that time, that amount of Bitcoin could be liquidated for more than $7 billion today.

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Original article posted on the CoinTelegraph.com site, by Turner Wright.

Article re-posted on Markethive by Jeffrey Sloe

September 2016 All Over Again: Number Of Bitcoin Whales Shatters Record Highs Following Recent Price Rally

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September 2016 All Over Again: Number Of Bitcoin Whales Shatters Record Highs Following Recent Price Rally

By Brenda Ngari – October 26, 2020

Bitcoin has been caught in a steady uptrend in recent weeks that has allowed it to sever its correlation to traditional financial markets. In fact, at just below $13,100, the flagship cryptocurrency posted its second-highest weekly close since early 2018 on Sunday.

As the price of bitcoin soared, so did the number of whales. According to data from on-chain analytics provider Glassnode, the BTC whale population hit a new all-time high yesterday. The number of addresses with at least 1,000 BTC jumped to 2,231 — the highest level seen since September of 2016.

In the past week alone, the number of BTC whales surged by a cool 2.6%. Similarly, the price of the world’s most valuable cryptocurrency increased by roughly 14%. The upward momentum was further boosted by PayPal’s announcement on upcoming bitcoin support.

Why Is The BTC Whale Population Rising?

In the crypto community, the term whale is used to describe investors with significant BTC holdings and who have the ability to move the market in either direction. Since the beginning of this year, this particular group of investors has grown by over 14%. 

On-chain analyst Willy Woo suggested that the increase in the number of whale addresses could be as a result of high-net-worth individuals and funds seeing bitcoin as a potential hedge against expansive money printing and betting on the asset with real money.

Indeed, multiple publicly traded companies and big money individual investors have revealed investments into the bellwether cryptocurrency in recent months. Wall Street veteran Paul Tudor Jones was the first to publicly disclose his BTC investment back in May. Since then, several companies have put their weight behind the cryptocurrency and it seems that this trend is just getting started.

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DISCLAIMER

The views expressed in the article are wholly those of the author and do not represent those of, nor should they be attributed to, ZyCrypto. This article is not meant to give financial advice. Please carry out your own research before investing in any of the various cryptocurrencies available.

The original article written by Brenda Ngari and posted on ZyCrypto.com.

Article reposted on Markethive by Jeffrey Sloe